Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study.

@article{Davidson1995IncreasedNE,
  title={Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study.},
  author={Maximilian Davidson and Brian C Shanley and Peter A. Wilce},
  journal={Brain research},
  year={1995},
  volume={674 1},
  pages={91-6}
}
Intrahippocampal injections of N-methyl-D-aspartic acid (NMDA) leads to neurodegeneration in a dose-dependent manner. Chronic administration of ethanol to animals leads to CNS tolerance and dependence. Hyperexcitability following ethanol withdrawal is thought to be related to increased sensitivity of the NMDA receptors. The purpose of this study was to investigate this predisposition to hyperexcitability by intrahippocampal injection of low dose of NMDA. Using control and ethanol-withdrawn male… CONTINUE READING