Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury.

@article{Shi2001IncreasedNO,
  title={Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury.},
  author={Y Q Shi and Rodica Mariana Niculescu and Dian Wang and Sundeep Patel and Kelly L. Davenpeck and Andrew Zalewski},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 5},
  pages={739-45}
}
Reactive oxygen species (ROS), produced by cellular constituents of the arterial wall, provide a signaling mechanism involved in vascular remodeling. Because adventitial fibroblasts are actively involved in coronary remodeling, we examined whether the changes in the redox state affect their phenotypic characteristics. To this end, superoxide anion production and NAD(P)H oxidase activity were measured in porcine coronary arteries in vivo, and the effect of ROS generation on adventitial… CONTINUE READING