Increased Muscle Stress-Sensitivity Induced by Selenoprotein N Inactivation in Mouse: A Mammalian Model for SEPN1-Related Myopathy

Abstract

Selenium is an essential trace element and selenoprotein N (SelN) was the first selenium-containing protein shown to be directly involved in human inherited diseases. Mutations in the SEPN1 gene, encoding SelN, cause a group of muscular disorders characterized by predominant affection of axial muscles. SelN has been shown to participate in calcium and redox… (More)
DOI: 10.1371/journal.pone.0023094

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@inproceedings{Rederstorff2011IncreasedMS, title={Increased Muscle Stress-Sensitivity Induced by Selenoprotein N Inactivation in Mouse: A Mammalian Model for SEPN1-Related Myopathy}, author={Mathieu Rederstorff and Perrine Castets and Sandrine Arbogast and J. Laine and St{\'e}phane Vassilopoulos and Maud Beuvin and Odile Dubourg and Alban Vignaud and Arnaud Ferry and Alain Krol and Val{\'e}rie Allamand and Pascale Guicheney and A. Ferreiro and A. Rodriguez Lescure}, booktitle={PloS one}, year={2011} }