Increased Microsatellite Instability and Epigenetic Inactivation of the Hmlh1 Gene in Head and Neck Squamous Cell Carcinoma

@article{Zuo2009IncreasedMI,
  title={Increased Microsatellite Instability and Epigenetic Inactivation of the Hmlh1 Gene in Head and Neck Squamous Cell Carcinoma},
  author={Chunlai Zuo and Haihong Zhang and H. Spencer and E. Vural and J. Suen and S. Schichman and B. Smoller and M. Kokoska and C. Fan},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2009},
  volume={141},
  pages={484 - 490}
}
OBJECTIVE: The study is designed to elucidate the relationship between epigenetic silencing of the hMLH1 (human MutL homologue 1) gene and microsatellite instability (MSI) and the prognostic values of hMLH1 promoter methylation and MSI in head and neck squamous cell carcinoma (HNSCC). STUDY DESIGN: Cross-sectional study. SETTING: Tertiary referral center. SUBJECTS AND METHODS: A total of 120 cases of HNSCC were analyzed for hMLH1 promoter hypermethylation, protein expression, and MSI by using… Expand
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Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation
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The results suggested that most esophageal SCC develop through defects in tumor suppressor genes (i.e. the suppressor pathway), and that MSI in esophagese SCC probably represent random replication errors rather than being associated with DNA mismatch repair deficiency. Expand
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