Increased Messenger RNA Level of the Inhibitory G Protein a Subunit Gia , 2 in Human End-Stage Heart Failure


In human heart failure the positive inotropic and cAMP-elevating effects of both j,-adrenoceptor agonists and phosphodiesterase inhibitors are diminished. This has been explained at least in part by an increase in the inhibitory signal-transducing G protein (G1) and unchanged stimulatory G protein (Gs). In the present study we determined the mRNA expression… (More)

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