Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation.

@article{SaderMazbar2013IncreasedLD,
  title={Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation.},
  author={O. Sader-Mazbar and Yelena Loboda and Martin Jos{\'e} Rabey and John P. M. Finberg},
  journal={British journal of pharmacology},
  year={2013},
  volume={170 5},
  pages={999-1013}
}
BACKGROUND AND PURPOSE Selective MAO type B (MAO-B) inhibitors are effective in potentiation of the clinical effect of L-DOPA in Parkinson's disease, but dopamine (DA) is deaminated mainly by MAO type A (MAO-A) in rat brain. We sought to clarify the roles of MAO-A and MAO-B in deamination of DA formed from exogenous L-DOPA in rat striatum depleted of dopaminergic, or both dopaminergic and serotonergic innervations. We also studied the effect of organic cation transporter-3 (OCT-3) inhibition by… CONTINUE READING
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