Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS

@inproceedings{Goovaerts2019IncreasedKA,
  title={Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS},
  author={Odin Goovaerts and Margu{\'e}rite Massinga-Loemb{\'e} and Pascale Ondoa and Ann Ceulemans and William Worodria and Harriet Mayanja-Kizza and Robert Colebunders and Luc Kestens},
  booktitle={PloS one},
  year={2019}
}
BACKGROUND Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory complication in HIV-TB co-infected patients receiving antiretroviral therapy (ART). The exact contribution of T cells, natural killer (NK) cells, and monocytes to TB-IRIS development remains unclear. Here, we studied the expression of exhaustion markers on lymphocytes at different intervals during ART. METHODS We compared 13 HIV-TB patients who developed TB-IRIS with 13 patients who did… CONTINUE READING

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