Increased K+ inhibits spontaneous contractions reduces myosin accumulation in cultured chick myotubes

@article{Bandman1982IncreasedKI,
  title={Increased K+ inhibits spontaneous contractions reduces myosin accumulation in cultured chick myotubes},
  author={Everett Bandman and Richard C. Strohman},
  journal={The Journal of Cell Biology},
  year={1982},
  volume={93},
  pages={698 - 704}
}
Increasing the K+ from 5.4 mM to 12 mM in the culture medium of developing chick myotubes causes an immediate cessation of spontaneous contractions and leads to an inhibition of myosin accumulation. The synthesis of myosin continues at the same rate in 12 mM K+ as in 5.4 mM K+ as measured by [3H]leucine incorporation into myosin corrected for differences in pool specific activity. Total protein synthesis and total protein accumulation are unaffected by growth in 12 mM K+. In addition, growth in… CONTINUE READING
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