Increased Ischemia-Induced Angiogenesis in the Staggerer Mouse, a Mutant of the Nuclear Receptor Ror


Ror is an orphan nuclear receptor. In homozygous staggerer mutant mice (Rora), a deletion within the Rora gene leads to an overexpression of inflammatory cytokines. Because inflammation and hypoxia are 2 key stimuli of ischemia-induced angiogenesis, we studied the role of Ror in this setting. Ischemia was induced by ligation of the right femoral artery in… (More)


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