Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1

@inproceedings{Go2011IncreasedIS,
  title={Increased Inflammatory Signaling and Lethality of Influenza H1N1 by Nuclear Thioredoxin-1},
  author={Young-Mi Go and Sang-Moo Kang and James R Roede and Michael Orr and D. H. P. Jones},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immune cells. Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses. METHODOLOGY/PRINCIPAL FINDINGS Transgenic… CONTINUE READING
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