Increased Infertility With Age in Men and Women

  title={Increased Infertility With Age in Men and Women},
  author={David B. Dunson and Donna D. Baird and Bernardo Colombo},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To estimate the effects of aging on the percentage of outwardly healthy couples who are sterile (completely unable to conceive without assisted reproduction) or infertile (unable to conceive within a year of unprotected intercourse). METHODS: A prospective fecundability study was conducted in a sample of 782 couples recruited from 7 European centers for natural family planning. Women aged 18–40 years were eligible. Daily intercourse records were used to adjust for timing and… 
Coital Frequency and the Probability of Pregnancy in Couples Trying to Conceive Their First Child: A Prospective Cohort Study in Japan
The results suggest that first, natural conception rates could potentially increase with more frequent and well timed intercourse, and second that further work is needed to understand why even in a motivated sample of women monitoring their fertile periods, both the conception and coitus rates were low.
Age and Time to Pregnancy for the First Child among Couples in Japan
Cumulative probability of conception at 12 months after discontinuing contraception was highest for women aged 24-26 years, and it was lower for higher ages, e.g. 66% (95% CI: 61%, 71%) at ages 30-32 and 48% at ages 36-38.
Men's body mass index and infertility.
This study adds further support that men with excess body weight are at increased risk of infertility and research is needed to see if weight loss improves fertility for these men.
The prevalence of couple infertility in the United States from a male perspective: evidence from a nationally representative sample
The prevalence of infertility based on male reporting is consistent with estimates of infertility in the US found in prospective cohort studies and CD studies based on female reporting, and suggest that male partners can reliably inform about couple infertility.
Factors Affecting Fertility
This chapter summarizes the most relevant factors that affect fertility, making evidence based recommendations where appropriate to better counsel patients to improve their ability to conceive.
Fertility and ageing.
The late 20th century trend to delay birth of the first child until the age at which female fecundity or reproductive capacity is lower has increased the incidence of age-related infertility and stimulated interest in the possible factors in the female and the male that may contribute to the decline in fecundities with age.
Infertility and impaired fecundity in the United States, 1982-2010: data from the National Survey of Family Growth.
Estimates and trends for infertility and impaired fecundity-two measures of fertility problems-among women aged 15-44 in the United States and among married, nulliparous women aged 35-44 are presented, reflecting greater delays in childbearing over this period.
Definition and prevalence of subfertility and infertility.
Under appropriate circumstances a basic infertility work-up after six unsuccessful cycles with fertility-focused intercourse will identify couples with significant infertility problems to avoid both infertility under- and over-treatment, regardless of age.
Fecundability and Sterility by Age: Estimates Using Time to Pregnancy Data of Japanese Couples Trying to Conceive Their First Child with and without Fertility Treatment
Fecundability is overall lower at higher ages, while interquartile ranges are overlapping, suggesting that inter-individual variability of fecundability within an age group is as large as the variability across age groups.


Age and infertility.
  • C. West
  • Medicine
    British medical journal
  • 1987
The research suggests that advancing age is not a major factor in infertility and couples should not be excluded from investigation and treatment on the basis of age alone.
The effect of age on female fecundity
Changes with age in the level and duration of fertility in the menstrual cycle.
Fertility for women's fertility begins to decline in the late 20s with substantial decreases by the late 30s, and fertility for men is less affected by age, but shows significant decline by theLate 30s.
Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS.
Overall, the study shows that a decrease in fecundability (conception rate per cycle) as a function of a woman's age is slight but significant after 30 years of age and marked after 35 years.
Delaying childbearing: effect of age on fecundity and outcome of pregnancy.
After the age of 31 the probability of conception falls rapidly, but this can be partly compensated for by continuing insemination for more cycles, and the probability for an adverse pregnancy outcome starts to increase at about the same age.
Treatment-independent pregnancy among infertile couples.
It is concluded that the potential for a spontaneous cure of infertility is high, that treatment for many classes of infertility should be evaluated by randomized clinical trials, and that in such trials random assignment of subjects to untreated control groups would be ethically acceptable.
Timing of Sexual Intercourse in Relation to Ovulation. Effects on the Probability of Conception, Survival of the Pregnancy, and Sex of the Baby
In a total of 625 menstrual cycles for which the dates of ovulation could be estimated, 192 pregnancies were initiated, as indicated by increases in the urinary concentration of human chorionic gonadotropin around the expected time of implantation.
Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby.
Among healthy women trying to conceive, nearly all pregnancies can be attributed to intercourse during a six-day period ending on the day of ovulation, and the timing of sexual intercourse in relation to ovulation has no influence on the sex of the baby.
Day-specific probabilities of clinical pregnancy based on two studies with imperfect measures of ovulation.
Methods that anticipate ovulation by several days (such as the assessment of cervical mucus) would be particularly useful for couples who want to time their intercourse either to avoid or facilitate conception.