Increased Infertility With Age in Men and Women

@article{Dunson2004IncreasedIW,
  title={Increased Infertility With Age in Men and Women},
  author={David B. Dunson and Donna D. Baird and Bernardo Colombo},
  journal={Obstetrics \& Gynecology},
  year={2004},
  volume={103},
  pages={51-56}
}
OBJECTIVE: To estimate the effects of aging on the percentage of outwardly healthy couples who are sterile (completely unable to conceive without assisted reproduction) or infertile (unable to conceive within a year of unprotected intercourse). METHODS: A prospective fecundability study was conducted in a sample of 782 couples recruited from 7 European centers for natural family planning. Women aged 18–40 years were eligible. Daily intercourse records were used to adjust for timing and… 
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451 Citations
Highly Influential Citations
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Background Citations
157
Methods Citations
14
Results Citations
9

451 Citations

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The prevalence of infertility based on male reporting is consistent with estimates of infertility in the US found in prospective cohort studies and CD studies based on female reporting, and suggest that male partners can reliably inform about couple infertility.
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This chapter summarizes the most relevant factors that affect fertility, making evidence based recommendations where appropriate to better counsel patients to improve their ability to conceive.
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The late 20th century trend to delay birth of the first child until the age at which female fecundity or reproductive capacity is lower has increased the incidence of age-related infertility and stimulated interest in the possible factors in the female and the male that may contribute to the decline in fecundities with age.
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TLDR
Estimates and trends for infertility and impaired fecundity-two measures of fertility problems-among women aged 15-44 in the United States and among married, nulliparous women aged 35-44 are presented, reflecting greater delays in childbearing over this period.
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TLDR
Under appropriate circumstances a basic infertility work-up after six unsuccessful cycles with fertility-focused intercourse will identify couples with significant infertility problems to avoid both infertility under- and over-treatment, regardless of age.
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TLDR
Fecundability is overall lower at higher ages, while interquartile ranges are overlapping, suggesting that inter-individual variability of fecundability within an age group is as large as the variability across age groups.
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