Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

@inproceedings{RodrguezCalvo2014IncreasedIC,
  title={Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes},
  author={Teresa Rodr{\'i}guez-Calvo and Olov Ekwall and Natalie Amirian and Jose Zapardiel-Gonzalo and Matthias G von Herrath},
  booktitle={Diabetes},
  year={2014}
}
Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and environmental factors that have been implicated in the pathogenesis of disease both as triggers and potentiators of β-cell destruction. CD8 T cells are the main cell type found in human islets, and they have been shown in vitro to be capable of killing β-cells overexpressing MHC class I. In this study, we report that CD8 T cells infiltrate the exocrine pancreas of diabetic subjects in high numbers and not… CONTINUE READING
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