Increased IL-6-production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome.

@article{Yamamoto1996IncreasedIB,
  title={Increased IL-6-production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome.},
  author={Tatsuya Yamamoto and Keiichi Ozono and Soji Kasayama and Kosei Yoh and Kenzo Hiroshima and Masatoshi Takagi and Sahohime Matsumoto and Toshimi Michigami and Kunihiro Yamaoka and Tadamitsu Kishimoto and Sho Okada},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 1},
  pages={30-5}
}
McCune-Albright syndrome (MAS) is characterized by café-au-lait spot, multiple endocrine hyperfunction, and polyostotic fibrous dysplasia. A somatic point mutation of Gsalpha protein was reported to decrease GTPase activity, leading to increase in the GSalpha-associated hormone actions via cAMP. IL-6 is known to stimulate osteoclast formation and in the IL-6 promoter, a cAMP responsive element has been identified. In this paper, we investigated the role of IL-6 in the bone lesions of MAS, using… CONTINUE READING