Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet

@inproceedings{Wang2012IncreasedHI,
  title={Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet},
  author={Xiaoke Wang and Aiguo Ge and Mengjie Cheng and Fangfang Guo and Min Zhao and Xiaoqi Zhou and Liegang Liu and Nianhong Yang},
  booktitle={Experimental diabetes research},
  year={2012}
}
Inflammation has been implicated in the hypothalamic leptin and insulin resistance resulting defective food intake during high fat diet period. To investigate hypothalamic inflammation in dietary induced obesity (DIO) and obesity resistant (DIO-R) rats, we established rat models of DIO and DIO-R by feeding high fat diet for 10 weeks. Then we switched half of DIO and DIO-R rats to chow food and the other half to high fat diet for the following 8 weeks to explore hypothalamic inflammation… CONTINUE READING
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