Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse Models.

@article{Smith2010IncreasedHW,
  title={Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse Models.},
  author={Karen Dell Brown Smith and Erica Peethumnongsin and Han Lin and Hui Zheng and Robia G. Pautler},
  journal={Magnetic resonance insights},
  year={2010},
  volume={4},
  pages={11-18}
}
Amyloid precursor protein (APP) is implicated in axonal elongation, synaptic plasticity, and axonal transport. However, the role of APP on axonal transport in conjunction with the microtubule associated protein tau continues to be debated. Here we measured in vivo axonal transport in APP knockout mice with Manganese Enhanced MRI (MEMRI) to determine whether APP is necessary for maintaining normal axonal transport. We also tested how overexpression and mutations of tau affect axonal transport in… CONTINUE READING
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