Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat.

@article{Ellis2000IncreasedHV,
  title={Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat.},
  author={Evelyn Ellis and Dennis L. Guberski and Marta Somogyi-Mann and Maria B Grant},
  journal={Free radical biology & medicine},
  year={2000},
  volume={28 1},
  pages={91-101}
}
Hyperglycemia in diabetes induces increased levels of hydrogen peroxide (H2O2), a reactive oxygen species generated by reduced nicotinamide adenine dinucleotide (NADH) oxidase. Nontoxic levels of H2O2 increase endothelial cell permeability. Using a model of non-insulin-dependent diabetes, the BBZ/Wor rat, we investigated retinal levels of H2O2, vascular endothelial growth factor (VEGF) and its receptors, VEGF-R1 and VEGF-R2 by transmission electron microscopy at sites of the blood-retinal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…