Increased GABAB receptor function in mouse frontal cortex after repeated administration of antidepressant drugs or electroconvulsive shocks.

@article{Gray1987IncreasedGR,
  title={Increased GABAB receptor function in mouse frontal cortex after repeated administration of antidepressant drugs or electroconvulsive shocks.},
  author={J. A. Gray and Alfred Richard Green},
  journal={British journal of pharmacology},
  year={1987},
  volume={92 2},
  pages={357-62}
}
1 Addition of baclofen to a medium containing slices of mouse frontal cortex inhibited the potassium-evoked release of 5-hydroxytryptamine (5-HT) in a concentration-dependent manner. The degree of inhibition was increased in frontal cortex tissue taken from animals treated for 14 days with amitriptyline (10 mg kg-1, twice daily) at all concentrations of baclofen tested (10(-6) M-10(-4) M). 2 Administration of either desipramine, mianserin or zimeldine (10 mg kg-1 daily) for 14 days also… CONTINUE READING

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