Increased GABAB Receptor Subtype Expression in the Nucleus of the Solitary Tract of the Spontaneously Hypertensive Rat

@article{Spary2008IncreasedGR,
  title={Increased GABAB Receptor Subtype Expression in the Nucleus of the Solitary Tract of the Spontaneously Hypertensive Rat},
  author={Emma J. Spary and Azhar Maqbool and Sikha Saha and Trevor F. C. Batten},
  journal={Journal of Molecular Neuroscience},
  year={2008},
  volume={35},
  pages={211-224}
}
Expression of GABAB receptor messenger RNA (mRNA) in the central nervous system was compared between the spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rat. Polymerase chain reaction (PCR) revealed all the isoforms except B1e in cortex, hypothalamus, and medulla oblongata. In the nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM), the B1a-c and 1 g isoforms were present as well as B2. Real-time PCR detected significantly higher levels of B1a (p < 0.01) and… CONTINUE READING