Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency.

  title={Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency.},
  author={Francesca Nasta and Federica Laudisi and Manolo Sambucci and Maria Manuela Rosado and Claudio Pioli},
  journal={Journal of immunology},
  volume={184 7},
Growing evidence is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. In the current study, we investigated the effects of PARP-1 deficiency on regulatory T cell differentiation. Increased numbers of regulatory CD4(+)CD25(+)/Foxp3(+) T cells were found in thymus, spleen, and lymph nodes of PARP-1 knockout (KO) mice compared with wild-type (WT) controls. The increased frequency of regulatory T cells in the periphery resulted in impaired… CONTINUE READING
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