Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis

  title={Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis},
  author={Breanne Mackenzie and Martina Korfei and Ingrid Henneke and Zaneta Sibinska and Xia Tian and Stefanie Hezel and Salma Dilai and Roxana Wasnick and Beate Schneider and Jochen Wilhelm and Elie El Agha and Walter Klepetko and Werner Seeger and Ralph Theo Schermuly and Andreas G{\"u}nther and Saverio Bellusci},
  booktitle={Respiratory research},
BACKGROUND Recent clinical studies show that tyrosine kinase inhibitors slow the rate of lung function decline and decrease the number of acute exacerbations in patients with Idiopathic Pulmonary Fibrosis (IPF). However, in the murine bleomycin model of fibrosis, not all tyrosine kinase signaling is detrimental. Exogenous ligands Fibroblast Growth Factor… CONTINUE READING