Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation

@article{Thimme2005IncreasedEO,
  title={Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation},
  author={R. Thimme and V. Appay and Marie Koschella and E. Panther and E. Roth and A. Hislop and A. Rickinson and S. Rowland-Jones and H. Blum and H. Pircher},
  journal={Journal of Virology},
  year={2005},
  volume={79},
  pages={12112 - 12116}
}
ABSTRACT The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus… Expand
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