Increased Expression of the Cardiac L-type Calcium Channel in Estrogen Receptor–deficient Mice

@article{Johnson1997IncreasedEO,
  title={Increased Expression of the Cardiac L-type Calcium Channel in  Estrogen Receptor–deficient Mice },
  author={Barry D. Johnson and Wei Zheng and Kenneth S. Korach and Todd Scheuer and William A. Catterall and Gabor M. Rubanyi},
  journal={The Journal of General Physiology},
  year={1997},
  volume={110},
  pages={135 - 140}
}
Steroid hormones control the expression of many cellular regulators, and a role for estrogen in cardiovascular function and disease has been well documented. To address whether the activity of the L-type Ca2+ channel, a critical element in cardiac excitability and contractility, is altered by estrogen and its nuclear receptor, we examined cardiac myocytes from male mice in which the estrogen receptor gene had been disrupted (ERKO mice). Binding of dihydropyridine Ca2+ channel antagonist… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Estradiol reverses a calcium-related biomarker of brain aging in female rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 3 Excerpts
Highly Influenced

Gender modulates cardiac phenotype development in genetically modified mice.

Cardiovascular research • 2004
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…