Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration

@article{Beckers2017IncreasedEO,
  title={Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration},
  author={Lien Beckers and Dieter Ory and Ivana Geric and Lieven D. Declercq and Michel Koole and Michael Kassiou and Guy Bormans and Myriam Baes},
  journal={Molecular Imaging and Biology},
  year={2017},
  volume={20},
  pages={94-102}
}
Activation of the innate immune system plays a significant role in pathologies of the central nervous system (CNS). In order to follow disease progression and evaluate effectiveness of potential treatments involved in neuroinflammation, it is important to track neuroinflammatory markers in vivo longitudinally. The translocator protein (TSPO) is used as a target to image neuroinflammation as its expression is upregulated in reactive glial cells during CNS pathologies. However, it remains unclear… CONTINUE READING
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