Increased Expression of Extracellular Glutathione Peroxidase in Mice with Dextran Sodium Sulfate-Induced Experimental Colitis

@article{Tham2002IncreasedEO,
  title={Increased Expression of Extracellular Glutathione Peroxidase in Mice with Dextran Sodium Sulfate-Induced Experimental Colitis},
  author={Doris M. Tham and John C. Whitin and Harvey Jay Cohen},
  journal={Pediatric Research},
  year={2002},
  volume={51},
  pages={641-646}
}
Extracellular glutathione peroxidase (E-GPx) is a selenoenzyme that reduces hydrogen peroxide and organic peroxides. All plasma glutathione peroxidase (GPx) activity in humans is attributable to E-GPx. The gastrointestinal (GI) tract also synthesizes and secretes E-GPx into the extracellular milieu. Endogenously generated oxidants have been implicated in inflammatory bowel disease (IBD). We evaluated E-GPx levels in a mouse model of IBD using dextran sodium sulfate (DSS). Histologic lesions of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Glutathione peroxidases.

Biochimica et biophysica acta • 2013
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.

American journal of physiology. Gastrointestinal and liver physiology • 2001

Similar Papers

Loading similar papers…