Increased Expression of CCL20 in Human Inflammatory Bowel Disease

  title={Increased Expression of CCL20 in Human Inflammatory Bowel Disease},
  author={Arthur Kaser and Othmar Ludwiczek and Sandra Holzmann and Alexander Rupert Moschen and Guenter Weiss and Barbara Enrich and Ivo W. Graziadei and Stefan Dunzendorfer and Christian J Wiedermann and Elisabeth M{\"u}rzl and Eveline Grasl and Zerina Jasarevic and Nikolaus Romani and Felix Albert Offner and Herbert Tilg},
  journal={Journal of Clinical Immunology},
Inflammatory bowel disease (IBD) constituting Crohn's disease (CD) and ulcerative colitis (UC) is related to a dysregulated T cell response. CCL20 attracts memory T lymphocytes and dendritic cells. We asked whether CCL20 expression is altered in IBD. Colonic biopsies were obtained from 114 subjects with IBD, non-IBD colitis, irritable bowel syndrome, and healthy controls. CCL20 and CCR6 mRNA expression was measured by Taqman-PCR, and protein secretion from colonic explant cultures (CEC) and its… CONTINUE READING