Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease

@article{Andresen2011IncreasedEO,
  title={Increased Expression of Beta-Defensin 1 (DEFB1) in Chronic Obstructive Pulmonary Disease},
  author={E. Andresen and G. G{\"u}nther and J. Bullwinkel and C. Lange and H. Heine},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
On-going airway inflammation is characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the key factors determining the decrease in lung function, an important clinical parameter of COPD, are not clear. Genome-wide linkage analyses provide evidence for significant linkage to airway obstruction susceptibility loci on chromosome 8p23, the location of the human defensin gene cluster. Moreover, a genetic variation in the defensin beta 1 (DEFB1) gene was… Expand
Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma
DAMPs activating innate and adaptive immune responses in COPD
Fundamental role for HIF-1α in constitutive expression of human β defensin-1
Epigenetics in idiopathic pulmonary fibrosis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease.
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
Molecular basis of chronic inflammation in lung diseases: new therapeutic approach.
The genetics of chronic obstructive pulmonary disease
...
1
2
3
4
5
...