Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas

@article{Klopfleisch2009IncreasedEO,
  title={Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas},
  author={R. Klopfleisch and A. Gruber},
  journal={Veterinary Pathology},
  year={2009},
  volume={46},
  pages={416 - 422}
}
  • R. Klopfleisch, A. Gruber
  • Published 2009
  • Biology, Medicine
  • Veterinary Pathology
    • The BRCA/RAD51 complex of tumor suppressor genes plays a major role in the DNA damage response. In this explorative study, BRCA1, BRCA2, and RAD51 mRNA expression was quantified in highly defined laser microdissected tissue samples of simple adenomas, adenocarcinomas of the mammary gland, and their lymph node metastases by real-time quantitative reverse transcription polymerase chain reaction. Expression levels in the tumors were normalized to the geometric mean of 3 housekeeping genes and… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    Overexpression of BRCA2 gene in sporadic breast tumours
    • 78
    • PDF
    BRCA1 expression in canine mammary dysplasias and tumours: relationship with prognostic variables.
    • 71
    Aberrations of the p53 tumor suppressor gene in various tumors in dogs.
    • 80
    Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.
    • 163
    Cloning and sequencing full length of canine Brca2 and Rad51 cDNA.
    • 35
    Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
    • 590
    COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic fmolecular markers
    • 65
    Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours.
    • 71
    Preclinical study COX-2 expression in canine and feline invasive mammary carcinomas : correlation with clinicopathological features and prognostic molecular markers
    • 33
    Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells.
    • 231
    • PDF