Increased Expression Levels of WAVE3 Are Associated with the Progression and Metastasis of Triple Negative Breast Cancer

@inproceedings{Kulkarni2012IncreasedEL,
  title={Increased Expression Levels of WAVE3 Are Associated with the Progression and Metastasis of Triple Negative Breast Cancer},
  author={Swati A. Kulkarni and Katarzyna Augoff and Louis Rivera and Brian McCue and Thaer Khoury and Adrienne E Groman and Li Zhang and Lili Tian and Khalid Sossey-Alaoui},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Breast Cancer (BC) is a heterogeneous disease comprised of at least five genetically distinct subtypes, which together form the second leading cause of cancer death in women in the United States. Within BC subtypes, those classified as Triple Negative BCs (TNBCs) exhibit dismal survival rates due to their propensity to develop distant metastases. We have identified the WAVE3 protein, which is a critical regulator of actin cytoskeleton dynamics that are required for the motility and… CONTINUE READING
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