Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression

@article{Habelhah1999IncreasedEE,
  title={Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression},
  author={Hasem Habelhah and Futoshi Okada and Masanobu Kobayashi and Kazumoto Nakai and Sungki Choi and Jun-ichi Hamada and Tetsuya Moriuchi and Mitsunori Kaya and Kohichi Yoshida and Kei Fujinaga and Masuo Hosokawa},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1771-1776}
}
In this study, we investigated the role of E1AF, a member of ets family transcription factor, in the acquisition of metastatic capacity by non-metastatic mouse fibrosarcoma cell clone, QR-32. The QR-32 cell clone grows progressively after co-implantation with gelatin sponge in syngeneic C57BL/6 mice. The cell lines (QRsP) established from arising tumors after the co-implantation exhibited enhanced tumorigenicity and pulmonary metastasis in vivo as compared with parent QR-32 cells. The enhanced… CONTINUE READING
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