Increased E-cadherin expression in ovarian surface epithelium: an early step in metaplasia and dysplasia?

@article{MainesBandiera1997IncreasedEE,
  title={Increased E-cadherin expression in ovarian surface epithelium: an early step in metaplasia and dysplasia?},
  author={Sarah L. Maines-Bandiera and Nelly Auersperg},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={1997},
  volume={16 3},
  pages={250-5}
}
Ovarian surface epithelium (OSE), the source of common epithelial carcinomas, is a simple mesothelium that during carcinogenesis acquires complex epithelial characteristics normally found in tubal, endometrial, and endocervical epithelia. These characteristics include the intercellular adhesive molecule E-cadherin. We examined cryostat sections of 12 normal ovaries by immunofluorescence and immunocytochemistry to determine whether E-cadherin is a component of normal OSE that is retained in… CONTINUE READING