Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines.

@article{Masuda1988IncreasedDR,
  title={Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines.},
  author={Hiroshi Masuda and Robert F. Ozols and Gi Ming Lai and Antonio Tito Fojo and Melvin Rothenberg and Thomas C. Hamilton},
  journal={Cancer research},
  year={1988},
  volume={48 20},
  pages={
          5713-6
        }
}
A human ovarian cancer cell line, A2780, derived from an untreated ovarian cancer patient and relatively sensitive to cisplatin was treated by stepwise incubation with cisplatin to produce a cisplatin-resistant variant, 2780CP. The relative abilities of these cell lines to repair cisplatin-induced damage to cellular DNA then was examined by measure of [3H]thymidine incorporation into normal density DNA separated from bromodeoxyuridine-substituted DNA on alkaline cesium chloride gradients. These… CONTINUE READING
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X - ray structure of the major adduci of the anticancer drug cisplatin with DNA : c / s [ Ot ( NHj ) 2 | d ( pGpG ) ) ]

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