Increased DNA-protein crosslinks in lymphocytes of residents living in chromium-contaminated areas

@article{Taioli1995IncreasedDC,
  title={Increased DNA-protein crosslinks in lymphocytes of residents living in chromium-contaminated areas},
  author={Emanuela Taioli and Anatoly Zhitkovich and Patrick Kinney and Iris G. Udasin and Paolo G. Toniolo and Max Costa},
  journal={Biological Trace Element Research},
  year={1995},
  volume={50},
  pages={175-180}
}
It has been known for a number of years that chromium-containing mine slags were used as landfill in residential areas of Hudson County, New Jersey. Since one of the major lesions induced in intact cells by chromate is the DNA-Protein crosslink, we have used this lesion as a biomarker of biological effect of chromium (Cr) exposure. We have previously developed a sensitive and easy-to-perform assay to detect DNA-Protein crosslinks, based on the selective K SDS precipitation of DNA associated… CONTINUE READING

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