Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.

@article{Yang2012IncreasedDM,
  title={Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.},
  author={Beatrice T. Yang and Tasnim A Dayeh and Petr A Volkov and Clare L. Kirkpatrick and Siri Malmgren and Xingjun Jing and Erik Renstr{\"o}m and Claes B Wollheim and Marloes Dekker Nitert and Charlotte Ling},
  journal={Molecular endocrinology},
  year={2012},
  volume={26 7},
  pages={
          1203-12
        }
}
Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 diabetes (T2D) in humans. Here we analyzed mRNA expression and DNA methylation of PDX-1 in human pancreatic islets from 55 nondiabetic donors and nine patients with T2D. We further studied epigenetic… CONTINUE READING
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