Increased DNA double-strand breaks and enhanced apoptosis in patients with lupus nephritis.

@article{Souliotis2015IncreasedDD,
  title={Increased DNA double-strand breaks and enhanced apoptosis in patients with lupus nephritis.},
  author={Vassilis L. Souliotis and Petros P. Sfikakis},
  journal={Lupus},
  year={2015},
  volume={24 8},
  pages={804-15}
}
OBJECTIVE DNA double-strand breaks (DSBs) lead to mutations, genomic instability and apoptotic death, whereas accumulation of apoptotic cells results in excessive autoantigen presentation and autoantibody formation. We aimed to measure DSB levels in lupus nephritis, a severe complication of the prototypic systemic autoimmune disease. METHODS The intrinsic DNA damage and the apoptosis induction/DSB levels were evaluated in peripheral blood mononuclear cells of six patients and 10 healthy… CONTINUE READING
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