Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.

@article{Matsumura2000IncreasedDC,
  title={Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.},
  author={Itaru Matsumura and Hirotoshi Tanaka and Akira Kawasaki and Junko Odajima and Hanako Daino and Kahoko Hashimoto and Hiroshi Wakao and Koichi Nakajima and Takashi Kato and Hitoshi Miyazaki and Yuzuru Kanakura},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 8},
  pages={5553-9}
}
At the late phase of megakaryocytopoiesis, megakaryocytes undergo endomitosis, which is characterized by DNA replication without cell division. Although a number of cell cycle regulatory molecules have been identified, the precise roles of these molecules in megakaryocytic endomitosis are largely unknown. In a human interleukin-3-dependent cell line transfected with the thrombopoietin (TPO) receptor c-mpl (F-36P-mpl), either treatment with TPO or the overexpression of activated ras (Ha-Ras(G12V… CONTINUE READING
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