Increased Cu/Zn superoxide dismutase-like immunoreactivity in the swollen axons of rats intoxicated chronically with β,β′-iminodipropionitrile

@article{Nishiyama1995IncreasedCS,
  title={Increased Cu/Zn superoxide dismutase-like immunoreactivity in the swollen axons of rats intoxicated chronically with β,β′-iminodipropionitrile},
  author={Kazutoshi Nishiyama and Shin Hye Kwak and Shigeo Murayama and Masanori Watanabe and Ichiro Kanazawa},
  journal={Neuroscience Letters},
  year={1995},
  volume={194},
  pages={205-208}
}
Abstract Demonstration of a genetic linkage between the Cu/Zn superoxide dismutase (SOD1) gene and familial amyotrophic lateral sclerosis (ALS) has aroused interest in the role of SOD1 in spinal motoneuronal death. We used chronically β,β′-iminodipropionitrile (IDPN)-intoxicated rats as a model of ALS and investigated SOD1 changes in the spinal cord by immunocytochemical and in situ hybridization techniques. Compared with control rats, SOD1-like immunoreactivity (SOD1-IR) increased in swollen… CONTINUE READING