Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis

  title={Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis},
  author={François Glowacki and Gr{\'e}goire Savary and Viviane Gnemmi and David Buob and Cynthia Van der Hauwaert and Jean-Marc Lo-Guidice and S{\'e}bastien Bouy{\'e} and Marc Hazzan and Nicolas Pottier and Micha{\"e}l Perrais and S{\'e}bastien Aubert and Christelle Cauffiez},
  booktitle={PloS one},
MicroRNAs (miRNAs) are a class of noncoding RNA acting at a post-transcriptional level to control the expression of large sets of target mRNAs. While there is evidence that miRNAs deregulation plays a causative role in various complex disorders, their role in fibrotic kidney diseases is largely unexplored. Here, we found a strong up-regulation of miR-21 in the kidneys of mice with unilateral ureteral obstruction and also in the kidneys of patients with severe kidney fibrosis. In addition, mouse… CONTINUE READING


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