Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis

@inproceedings{Glowacki2013IncreasedCM,
  title={Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis},
  author={François Glowacki and Gr{\'e}goire Savary and Viviane Gnemmi and David Buob and Cynthia Van der Hauwaert and Jean-Marc Lo-Guidice and S{\'e}bastien Bouy{\'e} and Marc Hazzan and Nicolas Pottier and Micha{\"e}l Perrais and S{\'e}bastien Aubert and Christelle Cauffiez},
  booktitle={PloS one},
  year={2013}
}
MicroRNAs (miRNAs) are a class of noncoding RNA acting at a post-transcriptional level to control the expression of large sets of target mRNAs. While there is evidence that miRNAs deregulation plays a causative role in various complex disorders, their role in fibrotic kidney diseases is largely unexplored. Here, we found a strong up-regulation of miR-21 in the kidneys of mice with unilateral ureteral obstruction and also in the kidneys of patients with severe kidney fibrosis. In addition, mouse… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

MicroRNA and Renal Allograft Monitoring

Nephro-urology monthly • 2013
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

International journal of biological sciences • 2011

Similar Papers

Loading similar papers…