Increased Cell Surface Free Thiols Identify Effector CD8+ T Cells Undergoing T Cell Receptor Stimulation

@inproceedings{Pellom2013IncreasedCS,
  title={Increased Cell Surface Free Thiols Identify Effector CD8+ T Cells Undergoing T Cell Receptor Stimulation},
  author={Samuel Troy Pellom and Ryan D. Michalek and Katie E. Crump and P. Kent Langston and Daniel G. Juneau and Jason M. Grayson},
  booktitle={PloS one},
  year={2013}
}
Recognition of peptide Major Histocompatibility Complexes (MHC) by the T cell receptor causes rapid production of reactive oxygen intermediates (ROI) in naïve CD8(+) T cells. Because ROI such as H2O2 are membrane permeable, mechanisms must exist to prevent overoxidation of surface proteins. In this study we used fluorescently labeled conjugates of maleimide… CONTINUE READING