Increased Cell‐surface Urokinase in Advanced Ovarian Cancer

  title={Increased Cell‐surface Urokinase in Advanced Ovarian Cancer},
  author={Hiroshi Kobayashi and Nobuhiko Moniwa and Motoi Sugimura and Hiromitsu Shinohara and Hidekazu Ohi and Toshihiko Terao},
  booktitle={Japanese journal of cancer research : Gann},
Urokinase-type plasminogen activator (uPA), uPA receptors, and cathepsin B were quantitated by using an immunological method, enzyme-linked immunosorbent assay, and amidolytic activity assays in 15 malignant and 10 benign epithelial ovarian tumors. The levels of uPA and uPA receptors, as well as cathepsin B, were found to be higher in membrane preparations obtained from malignant tumors than in those obtained from benign tumors. Acid-treated membranes acquired the ability to bind uPA… CONTINUE READING

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