Increased Cardiomyocyte Intracellular Calcium during Endotoxin-Induced Cardiac Dysfunction in Guinea Pigs

@article{Thompson2000IncreasedCI,
  title={Increased Cardiomyocyte Intracellular Calcium during Endotoxin-Induced Cardiac Dysfunction in Guinea Pigs},
  author={Marita Thompson and A. Kliewer and David L. Maass and L. Becker and D Jean White and Debora D. Bryant and Grace M. Arteaga and Jureta W. Horton and Brett P Giroir},
  journal={Pediatric Research},
  year={2000},
  volume={47},
  pages={669-676}
}
Septic shock is a complex pathophysiologic state characterized by circulatory insufficiency, multiple system organ dysfunction, and frequent mortality. Although profound cardiac dysfunction occurs during sepsis, the pathogenesis of this dysfunction remains poorly understood. To determine whether abnormalities in intramyocyte calcium accumulation might contribute to the development of cardiac dysfunction, we measured myocyte intracellular calcium during peak cardiac dysfunction after an… CONTINUE READING

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