Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells.

@article{Tang2012IncreasedCT,
  title={Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells.},
  author={Shuai Tang and Miranda L. Moore and Jason M. Grayson and Purnima Dubey},
  journal={Cancer research},
  year={2012},
  volume={72 8},
  pages={
          1975-85
        }
}
Although androgen ablation therapy is effective in treating primary prostate cancers, a significant number of patients develop incurable castration-resistant disease. Recent studies have suggested a potential synergy between vaccination and androgen ablation, yet the enhanced T-cell function is transient. Using a defined tumor antigen model, UV-8101-RE, we found that concomitant castration significantly increased the frequency and function of antigen-specific CD8(+) T cells early after the… CONTINUE READING

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