Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis

@inproceedings{Angelini2013IncreasedCT,
  title={Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis},
  author={Daniela Francesca Angelini and Barbara Serafini and Eleonora Piras and Martina Severa and Eliana M Coccia and Barbara Rosicarelli and Serena Ruggieri and Claudio Gasperini and Fabio Buttari and Diego Centonze and Rosella Mechelli and Marco Salvetti and Giovanna Borsellino and Francesca Aloisi and Luca Battistini},
  booktitle={PLoS pathogens},
  year={2013}
}
It has long been known that multiple sclerosis (MS) is associated with an increased Epstein-Barr virus (EBV) seroprevalence and high immune reactivity to EBV and that infectious mononucleosis increases MS risk. This evidence led to postulate that EBV infection plays a role in MS etiopathogenesis, although the mechanisms are debated. This study was designed to assess the prevalence and magnitude of CD8+ T-cell responses to EBV latent (EBNA-3A, LMP-2A) and lytic (BZLF-1, BMLF-1) antigens in… CONTINUE READING

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