Increased CD38 expression is associated with favorable prognosis in adult acute leukemia.

@article{Keyhani2000IncreasedCE,
  title={Increased CD38 expression is associated with favorable prognosis in adult acute leukemia.},
  author={Afsaneh Keyhani and Yang Huh and David B Jendiroba and Lance C. Pagliaro and Janet Cortez and Sherry M Pierce and Michael L Pearlman and Elihu E Estey and Hagop A Kantarjian and Emil J. Freireich},
  journal={Leukemia research},
  year={2000},
  volume={24 2},
  pages={153-9}
}
CD38 is expressed in acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) blasts and its prognostic significance is unknown. We investigated CD38 expression in 304 AML and 138 ALL patients. CD38 was lower in AML-M3 compared to other FAB subtypes (5% vs. 41%; P < 0.001), but was similar among ALL subtypes (56.6%; P = 0.69). Ph + ALL and AML with t(15; 17) patients showed lower CD38 expression than the other cytogenetic groups. Overall survival favored AML and ALL patients with… CONTINUE READING
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