Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial–Mesenchymal Transition-like Phenomenon

@article{Kim2011IncreasedCE,
  title={Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial–Mesenchymal Transition-like Phenomenon},
  author={Ho Min Kim and Naotsugu Haraguchi and Hideshi Ishii and Masahisa Ohkuma and Miho Okano and Koshi Mimori and Hidetoshi Eguchi and Hirofumi Yamamoto and Hiroaki Nagano and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori},
  journal={Annals of Surgical Oncology},
  year={2011},
  volume={19},
  pages={539-548}
}
Recently, it has been reported that a small population of cancer stem cells (CSCs) play a role in resistance to chemotherapy and radiation therapy. We reported that CD13+ liver CSCs survive in hypoxic lesions after chemotherapy, presumably through increased expression of CD13/Aminopeptidase N, which is a scavenger enzyme in the reactive oxygen species (ROS) metabolic pathway. On the other hand, the concept of epithelial–mesenchymal transition (EMT) was indicated by a recent study showing an… CONTINUE READING
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