Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury

@article{Fisher2015IncreasedCS,
  title={Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury},
  author={Paul W. Fisher and Yingjie Zhao and Mario C. Rico and Vicky S. Massicotte and Christine K. Wade and Judith Litvin and Geoffrey M Bove and Steven N. Popoff and Mary F. Barbe},
  journal={Journal of Cell Communication and Signaling},
  year={2015},
  volume={9},
  pages={37-54}
}
Key clinical features of cumulative trauma disorders include pain, muscle weakness, and tissue fibrosis, although the etiology is still under investigation. Here, we characterized the temporal pattern of altered sensorimotor behaviors and inflammatory and fibrogenic processes occurring in forearm muscles and serum of young adult, female rats performing an operant, high repetition high force (HRHF) reaching and grasping task for 6, 12, or 18 weeks. Palmar mechanical sensitivity, cold temperature… CONTINUE READING
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