Increased Bone Mass in Female Mice Lacking Mast Cell Chymase

Abstract

Here we addressed the potential impact of chymase, a mast-cell restricted protease, on mouse bone phenotype. We show that female mice lacking the chymase Mcpt4 acquired a persistent expansion of diaphyseal bone in comparison with wild type controls, reaching a 15% larger diaphyseal cross sectional area at 12 months of age. Mcpt4-/- mice also showed… (More)
DOI: 10.1371/journal.pone.0167964

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@inproceedings{Lind2016IncreasedBM, title={Increased Bone Mass in Female Mice Lacking Mast Cell Chymase}, author={Thomas Lind and A. Gustafson and Gabriela Calounova and Lijuan Hu and Annica J. Rasmusson and Kenneth Jonsson and Sara Wernersson and Magnus {\AA}brink and G{\"o}ran Andersson and Sune Larsson and H{\aa}kan Melhus and Gunnar Pejler}, booktitle={PloS one}, year={2016} }