Increased Aurora B activity causes continuous disruption of kinetochore – microtubule attachments and spindle instability

  • Marta Muñoz-Barreraa, Fernando Monje-Casasa
  • Published 2014

Abstract

Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Aurora B kinase function results in the inability to correct erroneous kinetochore–microtubule attachments and gives rise to aneuploidy. Interestingly, increased Aurora B activity also leads to problems with chromosome segregation, and overexpression of this… (More)

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