Increased Atherosclerotic Lesions in LDL Receptor Deficient Mice With Hematopoietic Nuclear Receptor Rev‐erbα Knock‐ Down

@inproceedings{Ma2013IncreasedAL,
  title={Increased Atherosclerotic Lesions in LDL Receptor Deficient Mice With Hematopoietic Nuclear Receptor Rev‐erbα Knock‐ Down},
  author={Hongling Ma and Wenbin Zhong and Yingliang Jiang and Coralie Fontaine and Shiqian Li and Jiangnan Fu and Vesa M Olkkonen and Bart Staels and Daoguang Yan},
  booktitle={Journal of the American Heart Association},
  year={2013}
}
BACKGROUND Nuclear receptor Rev-erbα plays important roles in circadian clock timing, lipid metabolism, adipogenesis, and vascular inflammation. However, the role of Rev-erbα in atherosclerotic lesion development has not been assessed in vivo. METHODS AND RESULTS The nuclear receptor Rev-erbα was knocked down in mouse haematopoietic cells by means of shRNA-lentiviral transduction, followed by bone marrow transplantation into LDL receptor knockout mice. The Rev-erbα protein in peripheral… CONTINUE READING