Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

Abstract

Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. These events are sufficient to trigger… (More)
DOI: 10.1016/j.cell.2014.05.012

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Cite this paper

@article{Lee2014IncreasedAO, title={Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity}, author={Yun Sok Lee and Jung-whan Kim and Olivia Osborne and Da Young Oh and R. S{\'a}sik and Simon Schenk and Ai Chen and Heekyung Chung and Anne Marie Murphy and Steven M. Watkins and Oswald Quehenberger and Randall S Johnson and Jerrold M. Olefsky}, journal={Cell}, year={2014}, volume={157}, pages={1339-1352} }