Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

@article{Lee2014IncreasedAO,
  title={Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity},
  author={Yun Sok Lee and Jung-whan Kim and Olivia J Osborne and Da Young Oh and R. S{\'a}sik and Simon Schenk and Ai Lin Chen and Heekyung Chung and Anne Murphy and Steven M. Watkins and Oswald Quehenberger and Randall S Johnson and Jerrold M. Olefsky},
  journal={Cell},
  year={2014},
  volume={157},
  pages={1339-1352}
}
Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. These events are sufficient to trigger HIF-1α induction, setting off the chronic adipose tissue inflammatory response characteristic of obesity. At the molecular level, these… CONTINUE READING
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HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression

  • B. Keith, R. S. Johnson, M. C. Simon
  • Nat. Rev. Cancer
  • 2012
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